This is the Second Edition of The Binding of Isaac: Four Souls. All cards have been updated with enhanced backgrounds and updated wording for clarity. The roster of characters is now greater than ever with the addition of Tainted characters. They'll be exploring the brand-new optional Room Deck for advanced play, which offers global modifiers for players, either cursing or blessing them with powerful effects as they fight to survive. It's not all doom and gloom though, charmed enemies turn foes into friends as players race to be the first to acquire Four Souls. The Binding of Isaac: Four Souls is a multi-player card game about sacrifice, betrayal and hoarding. In the game, 2-4 players take turns playing loot cards and using items to kill monsters that yield more items, loot, and sometimes souls. Cooperation, barter and betrayal is encouraged.