Pack of 200 threaded inserts. These create much more convenient and professional parts than using "captive nuts" (where you have to design a slot for a nut, and then place the nut in the slot and hold it there while affixing a screw). They also can be used in some situations where captive nuts just don't work. These are inserted into a hole in the print that is slightly smaller than the insert, and set in place using a soldering iron to melt the plastic around the insert. The inserts have a slight taper and small fins that the plastic flows around, resulting in an extremely strong bond.
Rather than adjust designs around the limitations of 3D printing (supports, print bed size, etc), divide your parts into separate components that fasten using these inserts and machine screws. Not only does this give you greater flexibility when designing a part, but also allows you to re-print only failed components rather than full assemblies - saving time and money.

Tips:

Hole size in your product should be slightly smaller than the insert, to allow plastic to flow between the insert's vanes.
Allow the insert time to heat up prior to inserting into the plastic part. The plastic needs to fully melt around the insert and flow between the "fins" for a strong bond