APAGARD PREMIO, containing a higher concentration of nano-mHAP, is especially recommended in daily use for its superior benefits in the areas of: Enhanced Brightness and gloss, Smoother and more stain-resistant enamel, Fresh breath, Hypersensitivity relief. For best effect from nano-mHAP toothpastes, we recommend that you: Place a small amount, 1 - 1.5 cm, on a toothbrush. Brush your teeth and gums gently but meticulously for about 3-5 minutes, ideally after each meal, 3 times/day is recommended. Rinse lightly and spit out after brushing, so that any residue of nano-mHAP remaining will enrich your saliva and continue its work. It is put Ingredients and Distributor Labeling in English on the package.