When Nancy Drew begins to investigate a potential poisoning at the botanical garden known as Magnolia Gardens, she soon becomes poisoned herself. In the small window before her symptoms take hold, Nancy manages to collect all of the evidence the player will need, and to interview the potential suspects. Someone at Magnolia Gardens is using the facility's dangerous plants for nefarious purposes, and Nancy needs your help to find out who before the culprit strikes again. To unearth the culprit, the player must figure out which suspect had the means, motive, and opportunity to commit the crime.