Pet Remedy's Natural De-Stress & Calming formula is a unique and clinically proven formula of Valerian absolute oil with small inclusions of Vetiver, Basil & Clary Sage essential oils. The low concentration of oils is very gentle in its effect and works with your pet's own natural calming mechanisms by mimicking GABA (gamma amino butyric acid), which is a natural calming agent present in mammals, birds, and reptiles. These calming wipes contain the same water based and pH neutral formula as Per Remedy calming spray, making them safe for use on skin and coat of pet. Ideal for travel, when out walking, or as an alternative for noise sensitive animals who dislike the sound of a spray. Starts to help instantly and the effects last for 2-6 hours depending on individual pet.