Niacin is a water-soluble B vitamin whose main role is to serve as a precursor for two essential biochemical coenzymes, NAD and NADP.* These two cofactors participate in virtually every aspect of energy production and other metabolic processes.* Niacin coenzymes help the cell use carbohydrates, fats, and proteins to produce energy and are critical for DNA replication and repair.* Inositol hexanicotinate is a stable, non-flushing source of niacin. This superior source of niacin works to reduce the common "niacin-flush" associated with high-dose niacin supplements.

The tolerable upper intake level for all forms of niacin for adults is 35mg/day based on flushing as the critical adverse effect; however, the form of niacin in this product is unlikely to cause a flushing response. High-dose niacin has been associated with liver dysfunction. Although this occurs most commonly with slow-release niacin, it can occur with any type of niacin when taken at a daily dose of > 500mg (usually ≥ 3g). Regular blood tests to evaluate liver function are recommended when using high-dose niacin. The anti-TB drug Isoniazid may increase the need for niacin. High-dose niacin may interact with statin drugs and may interfere with the absorption of tetracycline. If you are taking tetracycline, take at least two hours before or after taking niacin. Natural color variation may occur in this product.

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