Calamine Lotion Phenolated Hum 6oz Humco Holding Group Inc. - Skin protectant. Drying agent and Itch relief. Dries the oozing and weeping of poison ivy, poison oak, and poison sumac. Temporarily relieves the itching of the above and insect bites. Calamine lotion is an over-the-counter (OTC) medicine you can use to treat mild itchiness (pruritus). The topical pink lotion can help relieve itchiness, pain, and discomfort caused by conditions such as bug bites, chickenpox, and poison ivy.