Every ingredient in Flexicose is selected based on quality and stability. Microbiological evaluations are also conducted prior to bottling. Every batch has strict quality controls to ensure that all of the ingredients listed on the label are in fact included in the exact dosages stated. A majority of Flexicose customers report a reduction in pain and improved mobility within one to two weeks. For others it can take anywhere from six weeks to three months depending on the condition of your joints. Our bottles have a patented squeeze-and-sip measuring cup that ensures you are getting the correct daily dosage. Flexicose can be stored at room temperature before opening. It is recommended that you refrigerate after opening.