Backing Fabric is made from about 93.5% cotton and 6.5% spandex, it features a 100% medical grade hypoallergenic acrylic adhesive. It does not limit range of motion and can be worn three to five days at a time. Caution: Some individuals may be sensitive to acrylic adhesive and spandex. If a rash develops, discontinue use and consult a physician. Always consult a medical professional for advice about treatment of injuries or irritation. If discomfort or pain results, persists or increases, discontinue use and consult a physician.