Seachem KanaPlex formulation allows it to be absorbed through both the skin and gills of fish, making it effective even in cases where fish refuse food. It does not negatively impact the filter bed and can be easily removed from the aquarium with activated carbon. This product is suitable for use in both freshwater and marine aquaria and is effective.For dosing in water, it's recommended to remove all invertebrates due to their sensitivity to KanaPlex, turn off UV filters, ozone filters, and remove chemical filtration like MatrixCarbon and Purigen. One measure (included) should be used per every 20 liters (5 gallons), with doses repeated every 48 hours up to a maximum of three doses. A second round of treatment might be necessary, but only if the fish show no signs of stress at the end of the first treatment.