What is this medication? SIMETHICONE (sye METH i kone) treats the symptoms of gas, such as fullness, pressure, and bloating. It works by making it easier to pass gas through your digestive tract and exit your body. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. Take this medication by mouth. Use the special dropper included with the medication. Follow the directions on the label or those given to you by your care team. Do not take your medication more often than directed.