Boasting a unique, non-water based formula, the Regenerate Enamel Science Advanced Toothpaste uses exclusive and clinically proven NR-5 technology which forms a fresh supply of the same mineral tooth enamel is made of, restoring the high mineral content and protective function of tooth enamel with regular use. Directions for use: Advanced Toothpaste should be used daily, at least twice a day in place of your regular toothpaste. *Acts on early invisible stages of enamel erosion. Helps to regenerate enamel by restoring its mineral content and micro hardness with regular use. Clinically proven.