Dogzymes Estrus-mate contains organic red raspberry leaf powder, herbs and minerals as a nutritional source for the pre-breeding bitch. This product can be used between cycles to help support the cycle, used on an older bitch to assist in a successful cycle or used on a bitch who has had an irregular cycle. Completely natural, no fillers or preservatives. Recommended to start 30-60 days before the bitch comes into season. Once the bitch has been bred, switch to Dogzymes Gestamate for in utero puppy support. For best results, use with Nature's Farmacy Vita-Sorb vitamin complex and Dogzymes Ultimate for prenatal support. Active Ingredients per 1 Teaspoon (2.2 gm): A Proprietary Blend of: Lecithin Powder, Red Raspberry Leaf Powder, Maca Powder, Selenium Yeast.........1,463 mg Inactive Ingredients: Wild Harvested Kelp Directions for Use: Administer at meal time. For best results, administer in every meal.